Bariatric Times

AUG 2016

A peer-reviewed, evidence-based journal that promotes clinical development and metabolic insights in total bariatric patient care for the healthcare professional

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17 News and Trends Bariatric Times • August 2016 f ollowing The New York Times story, is now published in the August print edition of Obesity, the scientific journal of The Obesity Society, along with a second, new paper also examining m etabolic rates after weight loss. In a special mini-series in the journal, leading obesity experts weigh in on the two papers through two additional commentaries and an editorial, all of w hich explain the phenomenon of metabolic adaptation, or the process where weight loss is accompanied by a decline in energy (caloric) expenditure as weight is lost. These studies were c onducted on different populations, but reached the same conclusion: weight regain results from complex biological forces. The common accusation that individuals who don't keep the weight o ff just lack willpower is incorrect. "Obesity is a serious disease that cannot be 'cured' with weight loss," says Donna Ryan, MD, FTOS, Associate Editor in Chief of Obesity and s pokesperson for The Obesity Society. "Research is showing that once people lose weight and their metabolism slows, they experience an increase in appetite and a decrease in energy expenditure. These studies demonstrate that keeping the weight off long term requires constant vigilance and lifestyle changes to combat the biologic factors that are fighting to regain the weight." In the second paper released July 27, 2016, researchers Michael Rosenbaum, MD, and Rudolph L. Leibel, MD, examined 17 individuals with obesity first at their usual weight, again during maintenance of a 10% reduced weight, and a final time during maintenance of a 20% reduced weight. Their goal was to determine whether the reduction in energy expenditure was directly proportional to the amount of weight lost, if it was proportional up to a certain point, or if it was increasingly— or even exponentially—proportional. They found that all three models were effective. While these authors found that energy expenditure is explained by a combination of the three models, Fothergill et al's research on The Biggest Loser contestants seems to fall in line with the proportional model, where the more weight is lost the more the energy expenditure will decrease. "This study reinforces the complexities of obesity, illustrating that dramatic weight loss, such as that experienced by contestants from The Biggest Loser, may not be the best approach for keeping weight off long term," continued Dr. Ryan. "Efforts to maintain weight loss should focus on establishing sustainable diet and physical activity routines. While they may not lead to the dramatic weight loss experienced by contestant on The Biggest Loser, they can improve overall health and well-being." To read the full press release, which contains full links to the articles mentioned, please visit s s-releases/new-research-shows- keeping-the-weight-off-is-a-lot-more- than-willpower OBESITYWEEK 2016: MAJOR OBESITY SCIENTIFIC & MEDICAL CONFERENCE IN NEW ORLEANS, LA, OCT. 31 - NOV. 4 SILVER SPRING, Maryland—Get a glimpse into the future of obesity r esearch and treatment when more than 1,000 research abstracts are presented on new and emerging obesity treatments, the science of weight loss, new prevention strategies, metabolic s urgery, the genetics of obesity and public policy at the largest international conference on obesity. Thousands of l eading researchers, policymakers and healthcare professionals will gather for the fourth annual ObesityWeek conference at the New Orleans Ernest N. Morial Convention Center in L ouisiana from Oct. 31 – Nov. 4, 2016. The weeklong conference will feature the largest exhibit hall of its kind, showcasing the latest innovative products, services and technologies f rom obesity-focused companies and organizations worldwide. Keynote Speakers Offer Unique Perspectives Opening Keynote Speaker A ddresses Neural and Physiological Mechanisms Involved in Human Energy Balance, Nov. 2 G enetics of obesity expert, Professor Sadaf Farooqi PhD, FRCP, FMedSci, Wellcome Trust Senior Clinical Fellow and Professor of Metabolism and Medicine at the University of C ambridge Metabolic Research Laboratories offers the ObesityWeek 2016 opening keynote address. In her work, Dr. Farooqi is applying a genetic approach to help patients with early o nset obesity. She identified the first single gene defect to cause human obesity in patients with a mutation in the leptin gene, published in Nature in 1997, where she described the dramatic r esponse of these patients to leptin therapy.

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